TRANSLATIONAL PHYSIOLOGY Effects of inhaled carbon monoxide on acute lung injury in mice
نویسندگان
چکیده
Subhamay Ghosh, Michael R. Wilson, Sharmila Choudhury, Hirotoshi Yamamoto, Michael E. Goddard, Boglarka Falusi, Nandor Marczin, and Masao Takata Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London; and Department of Cardiothoracic Surgery and Anaesthetics, Imperial College London, and Heart Science Centre, Harefield Hospital, Harefield, United Kingdom
منابع مشابه
Effects of inhaled carbon monoxide on acute lung injury in mice.
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are major causes of morbidity and mortality in the intensive care unit, but despite continuing research few effective therapies have been identified. In recent years, inhaled carbon monoxide (CO) has been reported to have cytoprotective effects in several animal models of tissue injury. We therefore evaluated the effects of ...
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Polymorphonuclear leukocyte (PMN)-mediated acute lung injury from ischemia/reperfusion (I/R) remains a major cause of morbidity and mortality in critical care medicine. Here, we report that inhaled low-dose carbon monoxide (CO) and intravenous resolvin D1 (RvD1) in mice each reduced PMN-mediated acute lung injury from I/R. Inhaled CO (125-250 ppm) and RvD1 (250-500 ng) each reduced PMN lung inf...
متن کاملProtective effects of inhaled carbon monoxide in pig lungs during cardiopulmonary bypass are mediated via an induction of the heat shock response.
BACKGROUND Cardiopulmonary bypass (CPB) may cause acute lung injury leading to increased morbidity and mortality after cardiac surgery. Preconditioning by inhaled carbon monoxide reduces pulmonary inflammation during CPB. We hypothesized that inhaled carbon monoxide mediates its anti-inflammatory and cytoprotective effects during CPB via induction of pulmonary heat shock proteins (Hsps). METH...
متن کاملCarbon monoxide inhalation reduces pulmonary inflammatory response during cardiopulmonary bypass in pigs.
BACKGROUND Cardiopulmonary bypass (CPB) is associated with pulmonary inflammation and dysfunction. This may lead to acute lung injury and acute respiratory distress syndrome with increased morbidity and mortality. The authors hypothesized that inhaled carbon monoxide before initiation of CPB would reduce inflammatory response in the lungs. METHODS In a porcine model, a beating-heart CPB was u...
متن کاملLow-dose carbon monoxide treatment attenuates early pulmonary neutrophil recruitment after acid aspiration.
Exogenous carbon monoxide (CO) has anti-inflammatory and cytoprotective properties that show promise in the treatment of numerous pulmonary diseases. However, the effectiveness of CO in acute pulmonary injury associated with direct lung insult has not been shown conclusively. The purpose of this study was to determine if exogenous CO would modulate the pulmonary inflammation and lung injury tha...
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تاریخ انتشار 2005